The Fox River basin is a relatively small system of streams which drains 400 square miles in northeastern Missouri and southeastern Iowa upstream of the gage station on Fox River at Wayland, Missouri. The four largest streams in the basin are Fox River (52 miles long in Missouri), Little Fox River (24 miles in Missouri), Honey Creek (36 miles), and Sugar Creek (16 miles). Approximately 20% of basin stream mileage is channelized. While the Fox River itself is virtually unaltered, channelized reaches comprise 49% of Little Fox River, 41% of Sugar Creek, and 28% of Honey Creek. Fox River and its largest tributary, the Little Fox River, originate in southeastern Iowa. Both streams travel in a southeasterly direction before they join approximately 2.25 miles northwest of Kahoka, Missouri. In Missouri, the Little Fox River flows through northeastern Scotland County into northwestern Clark County to its confluence with Fox River, which flows through Clark County to its confluence with the Mississippi River approximately 7.5 miles southwest of Keokuk, Iowa. Major tributaries to the lower Fox River are Honey Creek and Sugar Creek. Honey Creek originates in west-central Clark County, flows southeasterly to U.S. Highway 61, then northeast to its confluence with Fox River approximately 2.5 miles southeast of Alexandria, Missouri. Sugar Creek originates near Kahoka and flows southeastward to its confluence with Honey Creek in southeastern Clark County. 67% of Fox River anglers fish primarily for channel catfish. Several anglers have reported catching big flatheads during high-flow periods in late spring and early summer. Fox River receives very little attention by anglers or floaters. Boating and canoeing on all tributaries and most of Fox River is hampered by shallow water, log jams, and low base flow. Even though recreational use of basin streams seems low relative to the availability of public stream frontage, there are some unique habitats which might be enjoyed if they were accessible.
The Fox River is the name of several places and rivers: